Nefopam & Nemuslide
The mechanism of action of nefopam and
its analgesic effects are not well understood,
although inhibition of
the reuptake of serotonin, nor epinephrine, and to a lesser
extent dopamine (that is, acting as an SNDRI is thought to be
involved. It also reduces glutamate signaling via
modulating sodium and calcium channels
Nimesulide is a prescription non-steroidal anti-inflammatory
drug with a multifactorial mode of action, characterized by a fast onset of
analgesic activity. This NSAID is a weak inhibitor of PG synthesis and
moderately COX-2 Selective. Anti-inflammatory action may be exerted by other
mechanisms as well, e.g. reduced generation of superoxide by neutrophils,
inhibition of PAF synthesis and TNFa release, free scavenging, inhibition of
metalloproteinase activity in cartilage.
Reference
Tripathi K.D.,” Essentials of Medical Pharmacology”, Jaypee
Brothers Medical Publishers (P) LTD, New Delhi, Seventh Edition, Pg No. 207,
208
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