Thursday, April 5, 2018

Nefopam & Nemuslide

Nefopam & Nemuslide
The mechanism of action of nefopam and its analgesic effects are not well understood, although inhibition of the reuptake of serotonin, nor epinephrine, and to a lesser extent dopamine (that is, acting as an SNDRI is thought to be involved. It also reduces glutamate signaling via modulating sodium and calcium channels

Nimesulide is a prescription non-steroidal anti-inflammatory drug with a multifactorial mode of action, characterized by a fast onset of analgesic activity. This NSAID is a weak inhibitor of PG synthesis and moderately COX-2 Selective. Anti-inflammatory action may be exerted by other mechanisms as well, e.g. reduced generation of superoxide by neutrophils, inhibition of PAF synthesis and TNFa release, free scavenging, inhibition of metalloproteinase activity in cartilage.

Reference

Tripathi K.D.,” Essentials of Medical Pharmacology”, Jaypee Brothers Medical Publishers (P) LTD, New Delhi, Seventh Edition, Pg No. 207, 208
















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