Sunday, April 8, 2018


Ezetimibe inhibits the absorption of cholesterol from the small intestine and decreases the amount of cholesterol normally available to liver cells, leading them to absorb more from circulation and thus lowering levels of circulating cholesterol the exact mechanism is not known, but it appears that ezetimibe blocks the critical mediator of cholesterol absorption the Niemann-Pick C1-like1 (NPC1C1) protein on the gastrointestinal tract epethilial cells as well as hepatocytes, blocks aminopepetidase N, and interrupts a Caveolin 1-Annoxin A2 complex involved in trafficking cholesterol.

Reference: Tripathi KD; Essentials of Clinical Pharmacology; Jaypee Brothers Medical Publishers; seventh edition; Page no: 635


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