Ezetimibe
inhibits the absorption of cholesterol from the small intestine and decreases
the amount of cholesterol normally available to liver cells, leading them to
absorb more from circulation and thus lowering levels of circulating
cholesterol the exact mechanism is not known, but it appears that ezetimibe
blocks the critical mediator of cholesterol absorption the Niemann-Pick
C1-like1 (NPC1C1) protein on the gastrointestinal tract epethilial cells as
well as hepatocytes, blocks aminopepetidase N, and interrupts a Caveolin
1-Annoxin A2 complex involved in trafficking cholesterol.
Reference: Tripathi KD;
Essentials of Clinical Pharmacology; Jaypee Brothers Medical Publishers;
seventh edition; Page no: 635
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