Sunday, April 8, 2018

Ezetimibe


Ezetimibe inhibits the absorption of cholesterol from the small intestine and decreases the amount of cholesterol normally available to liver cells, leading them to absorb more from circulation and thus lowering levels of circulating cholesterol the exact mechanism is not known, but it appears that ezetimibe blocks the critical mediator of cholesterol absorption the Niemann-Pick C1-like1 (NPC1C1) protein on the gastrointestinal tract epethilial cells as well as hepatocytes, blocks aminopepetidase N, and interrupts a Caveolin 1-Annoxin A2 complex involved in trafficking cholesterol.

Reference: Tripathi KD; Essentials of Clinical Pharmacology; Jaypee Brothers Medical Publishers; seventh edition; Page no: 635



9 comments:

  1. Great Article! Thanks for sharing this types of article is very helpful for us! If you have any type of pain like chronic pain, back pain etc.
    Best Pharmacy Shop
    Order Pharmacy Online
    Buy Caverta Online
    Buy Abamune Online
    Buy Acaprol Online
    Buy Admenta Online
    Order Admenta Online

    ReplyDelete