Search This Blog

Sunday, April 8, 2018

Febuxostat


Febuxostat is a non-purine-selective inhibitor of xanthine oxidase. It works by non-competitively blocking the molybdenum pterin center which is the active site on xanthine oxidase. Xanthine oxidase is needed to successively oxidase both hypoxanthine and xanthine to uric acid. Hance, febuxostat inhibits xanthine oxidase, therefore reducing production of uric acid. Febuxostat inhibits both oxidised as well as reduced form of xanthine oxidase because of which febuxostat can't be easily displaced from the molybdenum pterin site.

Reference: Tripathi KD; Essentials of Clinical Pharmacology; Jaypee Brothers Medical Publishers; seventh edition; Page no: 213



at
Labels:

1 comment:

  1. modadoveSeptember 21, 2020 at 10:06 PM

    Have read many blogs in the net but have never come across such a well written blog. Good work keep it up.Buy Waklert Online

    ReplyDelete

Subscribe to: Post Comments (Atom)

 

  • NIFEDIPINE
    NIFEDIPINE: MECHANISM OF ACTION- •    It’s a prototype DHP with a rapid onset of action with short duration. •    It’s a calcium channel...
  • doxycycline
    Doxycycline   inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.   Doxycycline   has bacteriostatic activity a...
  • Metyrapone
    Metyrapone blocks cortisol synthesis by reversibly inhibiting steroid-11 beta hydroxylase. This stimulates ACTH secretion, which in tur...