Febuxostat
is a non-purine-selective inhibitor of xanthine oxidase. It works by
non-competitively blocking the molybdenum pterin center which is the active
site on xanthine oxidase. Xanthine oxidase is needed to successively oxidase
both hypoxanthine and xanthine to uric acid. Hance, febuxostat inhibits
xanthine oxidase, therefore reducing production of uric acid. Febuxostat
inhibits both oxidised as well as reduced form of xanthine oxidase because of
which febuxostat can't be easily displaced from the molybdenum pterin site.
Reference:
Tripathi KD; Essentials of Clinical Pharmacology; Jaypee Brothers Medical
Publishers; seventh edition; Page no: 213
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