Sunday, April 8, 2018

Midazolam


Midazolam- it is thought that the action of  benzodiazepenes such as midazolaam are mediated through the inhibitory neurotransmitter gamma-aminobutyric acid(GABA), which is one of the major inhibitory neurotransmitter in the brain. BZD’s increase the activity of  GABA, thereby producing a calming effect, relaxing skeletal muscles and inducing sleep. BZD’s bind to the benzodiazapene site on GABA-A receptors, which potentiates the effect of  GABA by increasing the frequency of chloride channel opening.

Reference: Tripathi K.D; Essentials of Clinical Pharmacology; Jaypee Brothers Medical Publishers; Seventh edition; Page no.378, 383, 405



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