Midazolam-
it is thought that the action of
benzodiazepenes such as midazolaam are mediated through the inhibitory
neurotransmitter gamma-aminobutyric acid(GABA), which is one of the major
inhibitory neurotransmitter in the brain. BZD’s increase the activity of GABA, thereby producing a calming effect,
relaxing skeletal muscles and inducing sleep. BZD’s bind to the benzodiazapene
site on GABA-A receptors, which potentiates the effect of GABA by increasing the frequency of chloride
channel opening.
Reference:
Tripathi K.D;
Essentials of Clinical Pharmacology; Jaypee Brothers Medical Publishers;
Seventh edition; Page no.378, 383, 405
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