EVEROLIMUS

                                                                         
IUPAC NAME: dihyroxy-12-hydroxyethoxy 19'30dimethoxy -pentone


FORMULA:  C53H83NO14


MOLAR MASS:  958.224g/mol


ROUTE OF ADMINISTRATION: Oral


HALF LIFE: 30hrs

THERAPEUTIC USES: 
Used to treat varrious type of cancers such as kidney,breast,pancreas,lungs,stomach,intestine
                       
Used in certain gentic disorder such as tuberous sclerosis complex
                       
Used as immunosppressant to prevents rejectionof organ transplants .


SIDE EFFECTS: DIarrhea,Vomiting
                         Weight loss
                         Nosebleeding
                         Hairloss
                         Headache
                         Pain full bleeding in periods
                         Kidney disease
                         Blood sugar level increase
                         Diabetes
                         Hypercholesterolemia


DRUG-DRUG INTERACTION   ;
Such as NATALIZUMAB ,RITUXIMAB, ACE INHIBITORS INCREASE THE RISK OF INFECTION.

 NOTE ; NOT USER FOR PREGNANT WOMEN AND NOT FOR THE NEW BORN BABIES          
References: Click Here

ETORICOXIB

                                                                 
IUPAC Name:    5-Chloro-6-methyl-3[4-(methylsulfonyl)phenyl]-2-3        bipyridine

Route of administration  :  Oral

Pharmacokinetics :  Bioavailability  100%,   Plasma protein bindig 92%,   half life 22 hours

Chemical Formula:                    C18H15ClN2O2S

Molar Mass :  358.842g/mol

Introduction:  ETORICOXIB is a selective COX-2 inhibitor from Merck & Co. Currently it is approved in more than 80 countries world wide but not in the US,where FOOD AND DRUG ADMINSTRATION (FDA) has required addition safety and efficacy data for etoricoxib before it is issued approval.

Therapeutic Indication ;  It is indicated for the treatment of
                                                                1. Rheumatoid arthritis
                                                                2.Psoriatic arthritis
                                                                3.Osteoarthritis
                                                                4. Ankylosing spondylitis
                                                                5. Chronic low back pain
                                                                6. Acute pain
                                                                7. Gout
ADR'S :    1. Feeling sick,vomiting,diarrhoea
                  2. Heart burn,dizziness
                  3.Sweeling of legs
                  4.High blood pressure
                  5.Rashes itching
                  6.Insumnia
                  7.Drowsiness
                  8.Mouth ulcer
                  9.Hallucination
                  10..Palpitation

Drug-Drug Interaction:           IT should not be taken with NSAID'S
                                             
Etoricoxib + cox-2 inhibitors   results to no reaction
Not used in stomach ulcer or bleeding from intestine

Referance: Click Here